CMV, Influenza and B Cells

Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine.

Vaccine. 2015 Feb 7. pii: S0264-410X(15)00128-0. doi: 10.1016/j.vaccine.2015.01.071. [Epub ahead of print]

Frasca D1, Diaz A2, Romero M2, Landin AM2, Blomberg BB2
Author information
1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA. Electronic address: dfrasca@med.miami.edu.
2Department of Microbiology and Immunology, University of Miami Miller School of  Medicine, Miami, FL 33101, USA.
Abstract
Cytomegalovirus (CMV)-seropositivity has been shown to have a negative effect on influenza vaccine-specific antibody responses. In this paper, we confirm and extend these results showing for the first time, a negative association between CMV-seropositivity and B cell predictive biomarkers of optimal vaccine responses. These biomarkers are switched memory B cells and AID in CpG-stimulated B cell cultures measured before vaccination which positively correlate with the serum response to the influenza vaccine. We also found that CMV-seropositivity is associated with increased levels of B cell-intrinsic inflammation and these both correlate with lower B cell function. Finally, CMV-seropositivity is associated with decreased percentages of individuals responding to the vaccine in both young and elderly individuals.

KEYWORDS:
Aging; B cell biomarkers; CMV; Influenza vaccine
PMID: 25659271 [PubMed – as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25659271

Highlights
• Influenza vaccination is less effective in CMV-seropositive individuals.
• B cell biomarkers of optimal vaccine responses are reduced by CMV-seropositivity.
• CMV-seropositivity is associated with increased intrinsic inflammation in B cells.


This study is important because anti-smokers claim that smokers are more likely to get flu. But their studies always ignore the role of infection, so they’re exploiting the circumstance that smokers are more likely to have been exposed to CMV, for socioeconomic reasons. In studies that don’t find a difference between smokers and non-smokers, this is presumably because smokers and non-smokers had similar rates of CMV infection. Many studies have shown that cytomegalovirus impairs immunity to influenza.

http://www.smokershistory.com/influenza.html#CMV

 

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