CMV Accelerates Epigenetic Aging

Cytomegalovirus infection accelerates epigenetic aging.

L Kananen, T Nevalainen, J Jylhävä, S Marttila, A Hervonen, M Jylhä, M Hurme. Exp Gerontol 2015 Oct 17 [Epub ahead of print].

Abstract
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e. correlating with the calendar age of an individual. Thus, the epigenetic clock based on these kind of DNAm changes could provide a new biomarker for human aging process, i.e. being able to separate the calendar and biological age. Information about the correlation of the time indicated by this clock to the various aspects of immunosenescence is still missing. As chronic cytomegalovirus (CMV) infection is probably one of the major driving forces of immunosenescence, we now have analyzed the correlation of CMV seropositivity with the epigenetic age in the Vitality 90 + cohort 1920 (122 nonagenarians and 21 young controls, CMV seropositivity rates 95% and 57%, respectively). The data showed that CMV seropositivity was associated with a higher epigenetic age in both of these age groups (median 26.5 vs. 24.0 (p < 0.02, Mann–Whitney U -test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes.

http://www.sciencedirect.com/science/article/pii/S0531556515300711

More about CMV and Aging

Meanwhile, AS USUAL, the anti-smokers are committing scientific fraud by ignoring the role of CMV infection in order to exploit the circumstance that smokers are more likely to have been infected by it, beginning in childhood.

Smoking, heavy alcohol use are associated with epigenetic signs of aging

Date: October 8, 2015
Source: American Society of Human Genetics
Summary:
      Cigarette smoking and heavy alcohol use cause epigenetic changes to DNA that reflect accelerated biological aging in distinct, measurable ways, according to research. The researchers estimated biological age using a previously validated epigenetic “clock” , calculated the difference between biological age and chronological age, and assessed the relationship between tobacco and alcohol use and premature aging.
http://www.sciencedaily.com/releases/2015/10/151008173505.htm

But despite all the sciency-looking smoke and mirrors, this is really just a glorified lifestyle questionnaire study, operating in exactly the same way to flatter the lifestyle preferences of the privileged by exploiting the misfortunes of the poor. It lets them blame the victims, while feeling smug and self-righteous about lying in our faces and trampling on our liberties. The anti-smokers are of the privileged class, and the US government exists to serve them and oppress us: Robert A. Philibert, MD, PhD and colleagues at the University of Iowa and other institutions have received millions of tax dollars to commit fraud for their war of cultural genocide against us.

https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=13EFCE0D4B84C6D67598B8961CAA4A01A2FFCEB861BF

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