This is the most important study in many years, and we can expect the public health establishment to ignore it. They get their paychecks for blaming smoking, so they’d rather do things wrong, not right!
Assortative mixing as a source of bias in epidemiological studies of sexually transmitted infections: the case of smoking and human papillomavirus. P Lemieux-Mellouki, M Drolet, J Brisson, EL Franco, MC Boily, I Baussano, M Brisson. Epidemiol Infect 2015 Nov 20:1-10 [Epub ahead of print].
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. JC Nault, S Datta, S Imbeaud, A Franconi, M Mallet, G Couchy, E Letouzé, C Pilati, B Verret, JF Blanc, C Balabaud, J Calderaro, A Laurent, M Letexier, P Bioulac-Sage, F Calvo, J Zucman-Rossi. Nat Genet 2015 Oct;47(10):1187-1193. “We found clonal integration of adeno-associated virus type 2 (AAV2) in 11 of 193 HCCs. These AAV2 integrations occurred in known cancer driver genes, namely CCNA2 (cyclin A2; four cases), TERT (telomerase reverse transcriptase; one case), CCNE1 (cyclin E1; three cases), TNFSF10 (tumor necrosis factor superfamily member 10; two cases) and KMT2B (lysine-specific methyltransferase 2B; one case), leading to overexpression of the target genes. Tumors with viral integration mainly developed in non-cirrhotic liver (9 of 11 cases) and without known risk factors (6 of 11 cases), suggesting a pathogenic role for AAV2 in these patients. In conclusion, AAV2 is a DNA virus associated with oncogenic insertional mutagenesis in human HCC.” Of the 11 patients, one had HCV, one HBV plus alcohol, and three tumors were alcohol-related. Three patients were female (Supplementary Table 2).
Cytomegalovirus infection accelerates epigenetic aging.
L Kananen, T Nevalainen, J Jylhävä, S Marttila, A Hervonen, M Jylhä, M Hurme. Exp Gerontol 2015 Oct 17 [Epub ahead of print].
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e. correlating with the calendar age of an individual. Thus, the epigenetic clock based on these kind of DNAm changes could provide a new biomarker for human aging process, i.e. being able to separate the calendar and biological age. Information about the correlation of the time indicated by this clock to the various aspects of immunosenescence is still missing. As chronic cytomegalovirus (CMV) infection is probably one of the major driving forces of immunosenescence, we now have analyzed the correlation of CMV seropositivity with the epigenetic age in the Vitality 90 + cohort 1920 (122 nonagenarians and 21 young controls, CMV seropositivity rates 95% and 57%, respectively). The data showed that CMV seropositivity was associated with a higher epigenetic age in both of these age groups (median 26.5 vs. 24.0 (p < 0.02, Mann–Whitney U -test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes.
More about CMV and Aging
Meanwhile, AS USUAL, the anti-smokers are committing scientific fraud by ignoring the role of CMV infection in order to exploit the circumstance that smokers are more likely to have been infected by it, beginning in childhood. Continue reading
The latest Gallup poll, from July 8-12, 2015: First, the good news – the amazing jump in the proportion of smokers who do NOT want to quit smoking. They asked:
“All things considered, would you like to give up smoking or not?”
58% yes, 42% no
The percentage of smokers who answer “no” has more than doubled since 2011, when only 20% said no! And that 42% is the highest since Gallup began asking that question in 1977!
And the so-so news: The proportion of smokers wavers between 19-21% between 2012 and 2015.
In most things, there has been no progress. The same proportion of people, 80%, believe that smoking is “very harmful” in 2015 as in 2002. It would be nice to know how many still agreed if they knew how the anti-smokers falsely blame smoking for heart disease that’s really caused by cytomegalovirus. And furthermore, that they systematically commit the same fraud with every disease they blame on smoking. And furthermore again, they use the same fraud to falsely blame other aspects of peoples’ lifestyles for diseases caused by infection. And this fraud extends throughout the government’s evaluation of chemicals, the better thereby to create phony health scares and impose unnecessary regulations. (And industry never attacks the fraud because they use toxicologists who are cut from the same cloth as the fraudsters.) And they get away with it because nobody has ever uttered a peep of criticism about it. The only way to make change happen is by speaking out about THIS!
The bad news is that a higher percentage, 24% versus 14%, want to make smoking “totally illegal” than in 1990. But regardless of what the public wants, the FDA committee on tobacco (which is for all practical purposes nothing but another tentacle of the arch-criminals in the Office on Smoking and Health in the CDC) is making contingency plans to do so.
Tobacco and Smoking / Gallup
The Center for Medicare and Medicaid Innovation, which was created under Section 1115A of the Social Security Act (added by section 3021 of the Affordable Care Act), has commenced the initial stages of tyrannizing the details of older peoples’ lives in the name of supposedly reducing heart disease risks. Its “Million Hearts®: CVD Model” will be recruiting 360 control and 360 intervention practices, with about 150,000 Medicare fee-for-service patients in each group. Needless to say, the American Heart Association is the primary instigator. And it’s coming under cover of the US Secretary of Health and Human Services announcement of their intention to shift 85% of all traditional (fee for service) Medicare payments to “quality and value” [sic] by 2016. Continue reading
Remember the truth about how they got their beloved “EPA” report on secondhand smoke. It wasn’t even written by real EPA scientists, because they were against calling secondhand smoke a human carcinogen, and said so in their reviews. Instead, it was written by handpicked anti-smokers of the most militant ilk, who used illegal pass-through contracts to conceal their role. And on the board of directors of the crooked company that handled the pass-throughs sat Fred Malek, who was both a director of anti-smoker Sen. Frank Lautenberg’s company, ADP, and the campaign manager for President George Herbert Walker Bush, by whose administration the fraudulent report was released. And the mass media have deliberately concealed the truth all these years so they can FORCE their political agenda on the American people. And THAT is how their fraudulent so-called science and equally fraudulent so-called democracy really operate! Continue reading