Tag Archives: cytomegalovirus

CMV Accelerates Epigenetic Aging

Cytomegalovirus infection accelerates epigenetic aging.

L Kananen, T Nevalainen, J Jylhävä, S Marttila, A Hervonen, M Jylhä, M Hurme. Exp Gerontol 2015 Oct 17 [Epub ahead of print].

Abstract
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e. correlating with the calendar age of an individual. Thus, the epigenetic clock based on these kind of DNAm changes could provide a new biomarker for human aging process, i.e. being able to separate the calendar and biological age. Information about the correlation of the time indicated by this clock to the various aspects of immunosenescence is still missing. As chronic cytomegalovirus (CMV) infection is probably one of the major driving forces of immunosenescence, we now have analyzed the correlation of CMV seropositivity with the epigenetic age in the Vitality 90 + cohort 1920 (122 nonagenarians and 21 young controls, CMV seropositivity rates 95% and 57%, respectively). The data showed that CMV seropositivity was associated with a higher epigenetic age in both of these age groups (median 26.5 vs. 24.0 (p < 0.02, Mann–Whitney U -test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes.

http://www.sciencedirect.com/science/article/pii/S0531556515300711

More about CMV and Aging

Meanwhile, AS USUAL, the anti-smokers are committing scientific fraud by ignoring the role of CMV infection in order to exploit the circumstance that smokers are more likely to have been infected by it, beginning in childhood. Continue reading

Depraved Senators’ Tantrum Over US Chamber of Commerce

(Washington, DC) – Today, U.S. Senators Richard Blumenthal (D-Conn.) and Dick Durbin (D-Ill.) led a letter with their colleagues Senators Sherrod Brown (D-Ohio), Jack Reed (D-R.I), Sheldon Whitehouse (D-R.I.), Al Franken (D-Minn.), Elizabeth Warren (D-Mass.), and Jeff Merkley (D-Ore.) to reconsider and refocus its efforts away from undermining global anti-smoking measures. Following reports of the Chamber’s lobbying to defeat anti-smoking regulations across the globe, the Senators wrote to Chamber President Tom Donahue citing the severe risk their efforts pose to worldwide public health and condemned the Chamber for using its name and power to stymie countries’ efforts to enforce life-saving tobacco restrictions. (Blumenthal, Durbin, Senate Colleagues, Urge US Chamber to Cease Efforts to Undermine Anti-Smoking Public-Health Measures. Wednesday, July 8, 2015.)

http://www.blumenthal.senate.gov/newsroom/press/release/blumenthal-durbin-senate-colleagues-urge-us-chamber-to-cease-efforts-to-undermine-anti-smoking-public-health-measures

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Obamacare’s Health Fascist Meddling in Medicare

The Center for Medicare and Medicaid Innovation, which was created under Section 1115A of the Social Security Act (added by section 3021 of the Affordable Care Act), has commenced the initial stages of tyrannizing the details of older peoples’ lives in the name of supposedly reducing heart disease risks. Its “Million Hearts®: CVD Model” will be recruiting 360 control and 360 intervention practices, with about 150,000 Medicare fee-for-service patients in each group. Needless to say, the American Heart Association is the primary instigator. And it’s coming under cover of the US Secretary of Health and Human Services announcement of their intention to shift 85% of all traditional (fee for service) Medicare payments to “quality and value” [sic] by 2016. Continue reading