Cytomegalovirus infection accelerates epigenetic aging.
L Kananen, T Nevalainen, J Jylhävä, S Marttila, A Hervonen, M Jylhä, M Hurme. Exp Gerontol 2015 Oct 17 [Epub ahead of print].
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e. correlating with the calendar age of an individual. Thus, the epigenetic clock based on these kind of DNAm changes could provide a new biomarker for human aging process, i.e. being able to separate the calendar and biological age. Information about the correlation of the time indicated by this clock to the various aspects of immunosenescence is still missing. As chronic cytomegalovirus (CMV) infection is probably one of the major driving forces of immunosenescence, we now have analyzed the correlation of CMV seropositivity with the epigenetic age in the Vitality 90 + cohort 1920 (122 nonagenarians and 21 young controls, CMV seropositivity rates 95% and 57%, respectively). The data showed that CMV seropositivity was associated with a higher epigenetic age in both of these age groups (median 26.5 vs. 24.0 (p < 0.02, Mann–Whitney U -test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes.
More about CMV and Aging
Meanwhile, AS USUAL, the anti-smokers are committing scientific fraud by ignoring the role of CMV infection in order to exploit the circumstance that smokers are more likely to have been infected by it, beginning in childhood. Continue reading
Remember the truth about how they got their beloved “EPA” report on secondhand smoke. It wasn’t even written by real EPA scientists, because they were against calling secondhand smoke a human carcinogen, and said so in their reviews. Instead, it was written by handpicked anti-smokers of the most militant ilk, who used illegal pass-through contracts to conceal their role. And on the board of directors of the crooked company that handled the pass-throughs sat Fred Malek, who was both a director of anti-smoker Sen. Frank Lautenberg’s company, ADP, and the campaign manager for President George Herbert Walker Bush, by whose administration the fraudulent report was released. And the mass media have deliberately concealed the truth all these years so they can FORCE their political agenda on the American people. And THAT is how their fraudulent so-called science and equally fraudulent so-called democracy really operate! Continue reading
“The public are encouraged to face punch #smokers if they dare light up in #Bristol” – TobaccoTactics UK
The UK’s National Health Service has resorted to the Nazi tactic of the pogrom to intimidate smokers! And the US government is sure to copy them if they get away with it!
Update: TobaccoTactics is run by the University of Bath’s Tobacco Control Research Group in its School of Public Health, among whom is Anna B. Gilmore, MBBS MSc PhD FFPH. Gilmore et al. have published a raft of tobacco control studies, including, “Support for a tobacco endgame strategy in 18 European countries.” It hardly needs to be said that “endgame” is the code word for outlawing tobacco.
Anna B. Gilmore at the University of Bath has received $1,290,944 from the US National Cancer Institute between 2011 and 2013, for the project “Tobacco Companies, Global Governance and Public Health.”
In 2014, she received a grant of £354,246 for “Understanding the impact of tobacco tax increases and tobacco industry pricing on smoking behaviours and inequalities,” from the UK National Institute for Health Research.